![the keynote show the keynote show](https://sust.unm.edu/common/images/climate-strike-pic.jpg)
Merck has a strong commitment to the development of new treatment options for people with prostate cancer. “We are grateful to the patients and investigators for their participation in this study.” Eliav Barr, senior vice president, head of global clinical development and chief medical officer, Merck Research Laboratories. We will continue to advance our clinical development program to evaluate KEYTRUDA-based combinations and novel candidates for patients with this disease,” said Dr. “Results from this study serve as an important reminder that metastatic prostate cancer remains very difficult to treat, and more research is needed.
![the keynote show the keynote show](http://i.pptstar.com/i/pp/01/374/ppt_slide1.jpg)
Results will be presented at an upcoming medical meeting.
The keynote show trial#
The safety profile of KEYTRUDA in this trial was consistent with that observed in previously reported studies. In the study, there were modest trends toward an improvement in both OS and rPFS for patients who received KEYTRUDA plus chemotherapy compared with chemotherapy alone however, these results did not meet statistical significance per the pre-specified statistical plan.
![the keynote show the keynote show](https://i.ytimg.com/vi/EhoHFX5TYOw/maxresdefault.jpg)
Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the Phase 3 KEYNOTE-921 trial evaluating KEYTRUDA in combination with chemotherapy (docetaxel) compared to chemotherapy alone did not meet its dual primary endpoints of overall survival (OS) and radiographic progression-free survival (rPFS) for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC).